Prognostic Factors

Cytidine Deaminase Expression Causes Drug Resistance

Published in Gene Therapy Weekly, March 1st, 1999

Cytidine deaminase (CDD) gene expression is associated with resistance to cytarabine (AraC) in acute myeloid leukemia (AML).

J.K. Schroder and colleagues from the University of Essen, Germany, investigated the role of CDD in AML ("Structural and Functional Analysis of the Cytidine Deaminase Gene in Patients with Acute Myeloid Leukaemia," British Journal of Haematology, December 1998;103(4):1096-1103).

"Gene transfer of the cytidine deaminase (CDD) cDNA has recently been shown to induce cellular resistance to cytarabine (AraC) in vitro," wrote Schroder et al. "To investigate the role for CDD in acute myeloid leukaemia (AML), we analyzed the CDD...

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Source: Gene Therapy Weekly (1999-03-01)

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