Physiopathology (Animal Models)

Telomere Loss Spells Trouble For Aging Mice

Published in Gene Therapy Weekly, March 15th, 1999

Mice lacking a gene for making telomeres - chromosomal elements with a conjectured but controversial role in aging and cancer - were found to go gray, lose hair faster, and recover less easily from the stress of surgery and chemotherapy than normal animals.

They also developed tumors more often and died earlier, a team of Dana-Farber Cancer Institute (DFCI) researchers reported in the March 5, 1999, issue of Cell. "Until now no one has shown the phenotypic effect of telomere loss on the aging organism," said Lenhard Rudolph, at DFCI and Harvard Medical School (HMS), and lead author of the study.

Telomeres - nubs of protein and nucleic acids poised...

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Source: Gene Therapy Weekly (1999-03-15)

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