Growth Factors
NFAT Implicated in Regulation of Endothelial Genes
Published in Gene Therapy Weekly, March 29th, 1999
Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation.
A.L. Armesilla and colleagues demonstrated that signaling triggered by VEGF induced DNA-binding and transcriptional activities of nuclear factor of activated T cells (NFAT) and AP-1 in human umbilical vein endothelial cells (HUVECs) ("Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: A...
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Source: Gene Therapy Weekly (1999-03-29)
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