"Adenoviral Nerve Growth Factor and beta-Galactosidase Transfer to Spinal Cord: A Behavioral and Histological Analysis."

According to the authors' abstract of an article published in Journal of Neurosurgery, "Object: The present study characterizes the time course and loci of gene expression induced by the administration of adenoviral vectors into spinal cord. Although a marked inflammatory response to these vectors occurred, no effect on spinal cord function was seen in the 1st post-operative week. The expression of transgenic genes delivered by viral vectors is being exploited throughout the nervous system. The present study utilized adenoviral vectors containing the Rous sarcoma virus (RSV) promoter and a nuclear localization signal to achieve transgenic expression in mammalian spinal cord. ...

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