"Gene Transfer to Mammalian Cells Using Genetically Targeted Filamentous Bacteriophage."

According to the authors' abstract of an article published in FASEB Journal, "We have genetically modified filamentous bacteriophage to deliver genes to mammalian cells. In previous studies, we showed that noncovalently attached fibroblast growth factor (FGF2) can target bacteriophage to COS-1 cells, resulting in receptor-mediated transduction with a reporter gene. Thus, bacteriophage, which normally lack tropism for mammalian cells, can be adapted for mammalian cell gene transfer. To determine the potential of using phage-mediated gene transfer as a novel display phage screening strategy, we transfected COS-1 cells with phage that were engineered to display FGF2 on their surface coat...

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