Genetics

Monte Carlo Markov Chain Sampling for AD

Published in Gene Therapy Weekly, May 10th, 1999

A recent study has shown that Monte Carlo Markov chain sampling is a promising option for the dissection of late-onset oligogenic diseases.

E.W. Daw et al. explored the process of locating genes for late-developing diseases ("Multipoint Oligogenic Analysis of Age-At-Onset Data with Applications to Alzheimer Disease Pedigrees," American Journal of Human Genetics, March 1999;64(3):839-851).

"It is usually difficult to localize genes that cause diseases with late ages at onset. These diseases frequently exhibit complex modes of inheritance, and only recent generations are available to be genotyped and phenotyped. In this situation, multipoint analysis...

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Source: Gene Therapy Weekly (1999-05-10)

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