Gene Transfer
"Ureteral Gene Transfer to Porcine Induced Strictures Using Endourologic Delivery of an Adenoviral Vector."
Published in Gene Therapy Weekly, May 24th, 1999
According to the authors' abstract of an article published in Journal of Urology, "Purpose: Direct gene transfer to the ureter is an attractive approach to prevent restenosis after endourologic management of ureteral strictures. We therefore assessed the rationale for adenovirus-mediated gene transfer in the ureter in vitro and in vivo using a porcine model. Materials and Methods: Primary cultures of porcine ureteral epithelial and stromal cells were infected with an adenoviral solution carrying a nucleus-targeted P-Galactosidase (p-Gal) reporter gene (6.5 108 pfu/ml). In addition, in order to mimic the human clinical situation, we have devised a model of...
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Source: Gene Therapy Weekly (1999-05-24)
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