Vector Development
"Targeted Vectors for Cystic Fibrosis Gene Therapy."
Published in Gene Therapy Weekly, May 24th, 1999
NIH Grant Number: 5R01HL50255-08. Grant Expires: August 31, 2001. Principle Investigator: David T. Curiel. Performing Organization: University of Alabama at Birmingham, Birmingham, Alabama. Description: "A variety of vector strategies have been proposed to accomplish gene therapy for cystic fibrosis (CF). In this regard, a great deal of interest has focused on the utility of replication-defective adenoviral vectors to achieve direct in situ CFTR gene delivery to affected airway epithelium. Towards this goal, this vector has demonstrated the capacity to achieve efficient gene transfer in vitro to human airway epithelial cells and in vivo to...
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Source: Gene Therapy Weekly (1999-05-24)
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