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Transgenics

New Way To Modify Mammalian Genes: Honolulu Transgenesis

Published in Gene Therapy Weekly, May 24th, 1999

University of Hawaii (UH) scientists in Honolulu, together with colleagues in Japan, have developed a method for producing transgenic mammals.

The method, dubbed Honolulu transgenesis, uses sperm to deliver genetic information (DNA) from one organism into the egg of another. The egg can then divide so that every cell in the new individual contains the introduced DNA.

The experiments demonstrated the method using DNA for jellyfish green fluorescent protein to make green mice, and are reported in the May 14, 1999, issue of Science.

The team, whose members made headlines in Summer 1998 with Honolulu cloning, reported success in...

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