Published in Gene Therapy Weekly, June 28th, 1999
CpG dinucleotides are far more common in bacterial genomes than in vertebrate DNA and quickly are recognized as foreign invaders by mammalian immune systems. Synthetic ODNs containing the bacterial CpG motif (CpG-ODNs) mimic bacterial DNA and directly activate B cells. However, they do not directly activate T cells.
Now Annette Oxenius of the University of Zurich, Switzerland, and colleagues have shown that immunization of mice with a peptide T-cell epitope together with CpG-ODNs can induce protective immunity to a viral...
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