Published in Gene Therapy Weekly, July 12th, 1999
Research has shown that transient global ischemia can result in selective neuronal damage of hippocampal CA1 neurons. In the Mongolian gerbil animal model, five minutes of bilateral common carotid artery occlusion effectively restricts forebrain blood flow. This results in a delayed neuronal death of CA1 pyramidal cells.
F.J. Antonawich and colleagues from the State University of New York explored gene therapy options for reducing neuronal death caused by transient ischemia ("BCL-2 Transduction, Using a Herpes Simplex Virus Amplicon, Protects Hippocampal Neurons from Transient...
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