Published in Gene Therapy Weekly, July 12th, 1999
As these so-called T-helper cells are the basis of cell-mediated immunity, the technique promises to revolutionize the discovery process for antitumor and antiviral vaccines as well as the diagnosis of autoimmune diseases.
"This genetic approach is generally applicable to the identification of autoantigens, mutated and xenogeneic antigens recognized by CD4+ T cells derived from patients with cancer, autoimmune diseases, or infectious diseases, and may be useful for the development of preventive and therapeutic vaccines," wrote Rong-Fu Wang and...
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