Published in Gene Therapy Weekly, July 26th, 1999
Y.T. Tai and colleagues from Harvard University School of Medicine explored a gene therapy anticancer strategy based on the BAX proapoptotic protein ("In Vivo Cytotoxicity of Ovarian Cancer Cells Through Tumor-Selective Expression of the Bax Gene," Cancer Research, May 1, 1999;59(9):2121-2126).
Research has demonstrated that the BAX protein induces cell death either directly, through its effects on mitochondrial function, or indirectly, by lowering the apoptotic threshold in response to certain chemotherapy agents.
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