Vector Development
DC-Chol/DOPE Liposomes are Good Non-Viral Vectors
Published in Gene Therapy Weekly, July 26th, 1999
P.S. Ajmani and colleagues from the University of Florida investigated cationic lipid formulations as non-viral vectors ("3 Beta [N-(N',N'-Dimethylaminoethane)-Carbamoyl] Cholesterol (DC-Chol)-Mediated Gene Delivery to Primary Rat Neurons: Characterization and Mechanism," Neurochemical Research, May 1999;24(5):699-703).
"Cationic lipid formulations consisting of 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the helper lipid dioleoylphosphatidylethanolamine (DOPE) (1.5:1 molar ratio) were prepared by solvent evaporation and sized by high pressure...
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Source: Gene Therapy Weekly (1999-07-26)
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