Published in Gene Therapy Weekly, July 26th, 1999
University of Michigan researchers Catherine M. Browning, David M. Markovitz, and colleagues have been developing a gene therapy approach to the treatment of AIDS. This approach targets the Tat activation-response (TAR) element of the AIDS virus by causing cells to express TAR decoys. They soak up the HIV protein Tat like a sponge, leaving less of it to bind to actual TAR and thus slowing a process essential to rapid HIV replication.
Now Browning et al. show that the HIV-2 TAR (TAR-2) actually binds HIV-1 Tat more efficiently than HIV-1 TAR (TAR-1).
"We have directly proven that...
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