Pathogenesis
TGF Alpha Production Is Higher in Tumorigenic Cells
Published in Gene Therapy Weekly, August 16th, 1999
A.M. Fernandes and colleagues from the U.S. National Cancer Institute, Maryland, recently demonstrated that human lung epithelial cells, overexpressing ErbB-2, formed tumors in nude mice only when high levels of TGF alpha were produced. Cells transfected with a TGF alpha antisense vector failed to form tumors in nude mice.
In order to further evaluate the importance of TGF alpha for tumorigenicity, and its stimulation of ErbB family signalling, they studied the production of other EGF family growth factors by these human lung epithelial...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (1999-08-16)
More Articles from Gene Therapy Weekly
- DMD Gene Therapy
Potential Therapy for Muscular Dystrophy Uses EBV-Vector - Cancer Gene Therapy
Anti-mdr1 Ribozyme Reverses Drug Resistance - Cancer Immunotherapy
Genetically Engineered Lymphoma Cells Induce Immunity - Genetic Manipulation
Molecular Switch Helps Expand Transduced Hematopoietic Cells - Parkinson's Disease
Engineered Astrocytes Show Promise as Therapy - Polycystic Ovary Syndrome (Etiology)
Follistatin Gene Linked to PCOS - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
