Published in Gene Therapy Weekly, August 16th, 1999
A.M. Fernandes and colleagues from the U.S. National Cancer Institute, Maryland, recently demonstrated that human lung epithelial cells, overexpressing ErbB-2, formed tumors in nude mice only when high levels of TGF alpha were produced. Cells transfected with a TGF alpha antisense vector failed to form tumors in nude mice.
In order to further evaluate the importance of TGF alpha for tumorigenicity, and its stimulation of ErbB family signalling, they studied the production of other EGF family growth factors by these human lung epithelial...
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