"Interleukin-4 Adenoviral Gene Therapy Reduces Production of Inflammatory Cytokines and Prostaglandin E-2 by Rheumatoid Arthritis Synovium ex vivo."

According to the authors' abstract of an article published in Journal of Investigative Medicine, "Background: The rheumatoid arthritis (RA) joint is characterized by an inflammatory synovial pannus which mediates tissue destruction. Interleukin (IL)-4 reduces the production of many proinflammatory cytokines, particularly by activated macrophages. Therefore, we examined the ability of adenovirally delivered IL-4 for the treatment of human RA to reduce the secretion of proinflammatory molecules. Methods: Adenoviral vectors encoding the genes for human IL-4 (AxCAIL-4) and bacterial beta-galactosidase (AxCAlacZ) were generated and examined for appropriate production...

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