Cancer Gene Therapy
PTEN Gene Transfer Sensitizes Tumor to Radiation
Published in Gene Therapy Weekly, August 30th, 1999
W. Wick and colleagues from the University of Tubingen, Germany, noted that the tumor suppressor gene PTEN (MMAC1, TEP1) encodes a dual-specificity phosphatase and is considered a progression-associated target of genetic alterations in human gliomas. Further analysis revealed that gene transfer of PTEN has therapeutic potential. Results were reported in the journal Oncogene ("PTEN Gene Transfer in Human Malignant Glioma: Sensitization to Irradiation and CD95L-Induced Apoptosis," Oncogene, July 8, 1999;18(27):3936-3943).
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Source: Gene Therapy Weekly (1999-08-30)
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