Vector Development

HIV Vectors Can Be Maintained without gag and env

Published in Gene Therapy Weekly, September 13th, 1999

HIV based vectors can function without the essential viral genes gag and env.

Y. Cui and colleagues from the University of Florida examined the possibility of deleting HIV splice sites and gag and env sequences from an HN type 1 recombinant vector. This vector was established in their laboratory as part of ongoing efforts to improve this vector system. Their data were published in the Journal of Virology ("Contributions of Viral Splice Sites and Cis-Regulatory Elements to Lentivirus Vector Function," Journal of Virology, July 1999;73(7):6171-6176).

"The mobile transgene constructs of most human immunodeficiency virus...

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Source: Gene Therapy Weekly (1999-09-13)

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