Vascular Gene Transfer
"Gene Transfer of Endothelial Nitric Oxide Synthase Improves Nitric Oxide-Dependent Endothelial Function in a Hypertensive Rat Model."
Published in Gene Therapy Weekly, September 20th, 1999
According to the authors' abstract of an article published in Cardiovascular Research, "Objective: We have shown previously that there is a relative nitric oxide deficiency at the level of vascular endothelium in the stroke-prone spontaneously hypertensive rat (SHRSP), a model of human essential hypertension, as compared to its normotensive reference strain Wistar Kyoto (WKY) rat. The aim of the current study was to investigate whether adenoviral-mediated gene transfer of an endothelial nitric oxide synthase (eNOS) cDNA (AdCMVeNOS) into carotid arteries of the SHRSP may improve endothelial function. Methods: Enzyme activity of the recombinant eNOS protein encoded by...
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Source: Gene Therapy Weekly (1999-09-20)
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