"Preparation and Characterization of a Liposomal (Oligo)nucleotide Carrier System for Targeting to the Endothelial Cells in the Liver."

According to an abstract submitted by the authors to the NATO Advanced Studies Institute Conference titled Targeting of Drugs: Strategies for Gene Constructs and Delivery, held June 24 - July 5, 1999, in Marathon, Greece, "We have previously demonstrated that liposomes, surface-modified with anionized albumins, e.g., aconitylated human serum albumin (Aco-HSA), can be targeted to and internalized in large quantities by the scavenger receptor on hepatic sinusoidal endothelial cells. In the present project, we want to exploit these observations by targeting liposome-associated, antisense oligonucleotides or DNA to the endothelial cells in order to suppress the expression of various...

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