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Cancer Gene Therapy

Adjuvant Therapy Uses p53 Gene Transfer

Published in Gene Therapy Weekly, September 27th, 1999

Adenovirus-mediated, wild-type p53 gene transfer can be used as adjuvant therapy after surgical resection of head and neck cancer, suggest clinical trial data.

G.L. Clayman and colleagues from the University of Texas M.D. Anderson Cancer Center investigated therapeutic options to improve the survival rate for patients with head and neck cancer. Their study was reported in the journal Clinical Cancer Research ("Adenovirus-Mediated Wild-Type p53 Gene Transfer as a Surgical Adjuvant in Advanced Head and Neck Cancers," Clinical Cancer Research, July 1999;5(7):1715-1722).

"A high incidence of locoregional failure contributes to the poor...

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