Vector Development

Crosslinked Nanoparticles Have Vector Potential

Published in Gene Therapy Weekly, September 27th, 1999

Shell crosslinked nanoparticles are being developed as gene transfer vehicles.

K.B. Thurmond and colleagues from Washington University, Missouri, demonstrated compaction of DNA with nanoscale biomimetic constructs which are robust synthetic analogs of globular proteins. Their work was reported in the journal Nucleic Acids Research ("Packaging of DNA by Shell Crosslinked Nanoparticles," Nucleic Acids Research, July 15, 1999;27(14):2966-2971).

"These constructs are similar to 15 nm in diameter, shell crosslinked, knedel-like (SCKs) nanoparticles, which are prepared by covalent stabilization of amphiphilic di-block co-polymer micelles, self-assembled...

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Source: Gene Therapy Weekly (1999-09-27)

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