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Genomics

katG Enhances DNA Repair in E. coli

Published in Gene Therapy Weekly, September 27th, 1999

The Mycobacterium tuberculosis katG gene appears able to enhance DNA repair in Escherichia coli.

It has been noted that the M. tuberculosis KatG enzyme, like most hydroperoxidase 1 (HP1)-type catalases, consists of two related domains, each with strong similarity to the yeast cytochrome c peroxidase.

"The catalase-peroxidase activity is associated with the amino-terminal domain but currently no definite function has been assigned to the carboxy-terminal domain, although it may play a role in substrate binding," researcher M.A. Mulder and colleagues wrote ("Involvement of the N- and C-Terminal Domains of Mycobacterium...

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