Published in Gene Therapy Weekly, October 11th, 1999
Traditional antimicrobial resistance is based on a germ's ability to mutate the site at which a drug exerts its effect. A more insidious form of protection comes from so-called transport or efflux proteins that pump the antibiotic out of an infected cell.
One of these efflux proteins is known as the membrane-bound efflux proton pump or Mef. The mef gene is able to move via conjugation from one Gram-positive microbe to another. Now a disturbing new study shows that the gene can move into Gram-negative bacteria as well.
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