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Gene-Based Strategy Reverses Vancomycin Resistance
Published in Gene Therapy Weekly, October 18th, 1999
Enterococcus resistant to multiple antibiotics - including vancomycin, currently the last line of defense - are an increasing threat, particularly in hospital environments.
Harvard researchers C. Torres-Viera and colleagues used gene transfer experiments to define the molecular pathogenesis of vancomycin-resistant Enterococcus (VRE). They learned that the enterococcal protein p-VanR induces the vanH-promoter sequence that in turn drives expression of the native enterococcal vanHAX gene cluster. They then attempted to...
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Source: Gene Therapy Weekly (1999-10-18)
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