Published in Gene Therapy Weekly, October 25th, 1999
E.C. Ohage and colleagues from the University of Munich, Germany, created intrabodies with gene therapy applications. Their study was reported in the Journal of Molecular Biology ("Intrabody Construction and Expression of A Synthetic Catalytic Fv Fragment," Journal of Molecular Biology, 1999;291(5):1129-1134).
"In general, proteins with structural disulfides cannot be expressed in the reducing environment of the cellular cytoplasm," wrote Ohage et al. "To overcome this folding problem, we have previously engineered stabilizing...
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