Cancer Gene Therapy
Bypassing Transdominant Inhibition of p53 Needed
Published in Gene Therapy Weekly, October 25th, 1999
E.S. Stavridi and colleagues from the Wistar Institute, Pennsylvania, studied protein interactions that interfere with p53-based cancer gene therapies. Their results were presented in a recent issue of Protein Science ("Change in Oligomerization Specificity of the p53 Tetramerization Domain by Hydrophobic Amino Acid Substitutions," Protein Science, September 1999;8(9):1773-1779).
"The tumor suppressor function of the wild-type p53 protein is transdominantly inhibited by tumor-derived mutant p53 proteins," wrote Stavridi et al. "Such transdominant...
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Source: Gene Therapy Weekly (1999-10-25)
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