Allergy Immunotherapy

Regulation of Allergic Mucosal Sensitization by Gene Transfer

Published in Gene Therapy Weekly, November 8th, 1999

"Expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in the airway allows allergic sensitization to ovalbumin (OVA) in an experimental protocol that others have shown to induce inhalation tolerance," researchers from Canada reported.

"The ensuing response is characterized by T helper (Th)2 cytokines, marked eosinophilia in the bronchoalveolar lavage fluid (BALF) and the tissue, and goblet-cell hyperplasia," wrote M.R. Stampfli and colleagues, McMaster University, Health Sciences Center. "These findings, which underscore the importance of the airway microenvironment in the development of immune responses to airborne antigens, prompted us to...

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Source: Gene Therapy Weekly (1999-11-08)

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