Cancer Gene Therapy

Mutant Necrosis Factor Induces Antitumor Response

Published in Gene Therapy Weekly, November 8th, 1999

A p75 tumor necrosis factor (TNF) receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity, researchers from Canada reported.

"The toxic effects of tumor necrosis factor alpha (TNF alpha) have greatly limited its use in tumor therapy," wrote R.A. Marr and colleagues, McMaster University. "Recently, clear evidence has been obtained linking the p55 TNF receptor (TNFR) to the induction of systemic toxicity. We have generated a p75 murine TNFR (mTNFR)-specific mutant of mTNF alpha (D142 N-A144R), cloned this gene into a recombinant adenovirus vector (Ad-75), and studied its...

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Source: Gene Therapy Weekly (1999-11-08)

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