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Neuroblastoma Gene Therapy

Tumor Antigen Suppression May Inhibit Neuroblastoma

Published in Gene Therapy Weekly, November 15th, 1999

Inhibition of the large tumor antigen (T-ag) of the human polyomavirus BK (BKV) may be a potential treatment of neuroblastoma.

T. Flaegstad and colleagues from the University of Tromso, Norway, and the Karolinska Institute, Sweden, evaluated the possible oncogenic effect of BK virus by studying the molecular mechanisms of its T-ag in neuroblastoma cell lines.

They presented their study at the joint meeting of the International Society of Pediatric Oncology, the American Society for Pediatric Hematology/Oncology and the 31st Annual Meeting of the International Society of Pediatric Surgical Oncology, held September 13-18, 1999, in Montreal, Canada. ...

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