Herpes Simplex Virus 1 Vaccine

Bacterial Artificial Chromosomes Exploited as DNA Vaccine

Published in Gene Therapy Weekly, November 29th, 1999

BAC-VAC is a vaccine created from bacterial artificial chromosome (BAC) that induces protective immunity against herpes simplex virus 1 (HSV-1).

Mark Suter and colleagues from institutions in Switzerland, Australia, and The Netherlands, created a novel DNA vaccine combining BAC with a replication-competent, packaging-defective virus genome. Their study results were reported in a recent issue of the Proceedings of the National Academy of Sciences ("BAC-VAC, a Novel Generation of DNA Vaccines: A Bacterial Artificial Chromosome (BAC) Containing a Replication-Competent, Packaging-Defective Virus Genome Induces Protective Immunity against Herpes Simplex Virus 1," PNAS,...

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Source: Gene Therapy Weekly (1999-11-29)

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