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Drug Discovery

Gene-Trapping Strategies May Aid Drug Research

Published in Gene Therapy Weekly, December 27th, 1999

Genome-wide gene-trapping strategies may prove to be valuable assays for drug research.

"With sequence analysis of the human genome well underway, there is an increasingly urgent challenge to understand the fundamental function and interplay of genes that build and maintain an organism," wrote K. Durick, Aurora Biosciences Corporation, San Diego, California, and colleagues ("Hunting with Traps: Genome-Wide Strategies for Gene Discovery and Functional Analysis," Genome Research, November 1999;9(11):1019-1025).

"Several approaches will be critical for interpreting gene function, including random cDNA sequencing, expression profiling in different...

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