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Drug Development (Anticancer Agents)

PEI/DNA Complex Good Delivery Vehicle

Published in Gene Therapy Weekly, January 13th, 2000

by Michelle Marble -- Polyethyleneimine (PEI)/DNA complexes make good encapsulation agents for the delivery of intercalating drugs to cancer cells, suggest researchers from Texas.

C.A. Nichol and colleagues from the University of Texas MD Anderson Cancer Center, Texas, sought to develop a method of encapsulating intercalating agents in polymeric particles that could penetrate the cell membrane and deliver these materials to the cell nucleus. Results of their work were presented at the 1999 Annual Meeting of the American Association for Pharmaceutical Scientists, held November 14-18, 1999, in New Orleans, Louisiana. The title of their study was "Delivery of...

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