Vector Development
Mammalian Artificial Chromosomes as Autonomous Vectors
Published in Gene Therapy Weekly, January 13th, 2000
"They would not require insertion into the genome and could include sufficient genomic sequences that surround the therapeutic gene to ensure proper tissue-specific and temporal regulation," wrote P.E. Warburton and colleagues from the CUNY Mt. Sinai School of Medicine, Department of Human Genetics, New York. "Several groups have reported successful formation of MACs in human cells using transfection strategies that included alpha satellite DNA, the primary DNA found at normal human...
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Source: Gene Therapy Weekly (2000-01-13)
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