Cancer Gene Therapy
B7.1 Gene Transfer Improves T-Cell Activation
Published in Gene Therapy Weekly, February 10th, 2000
"Expression of B7 on tumor cells can circumvent T-cell tolerance and lead to the generation of tumor cell specific T-cell immunity," wrote P. T. Daniel and colleagues from Humboldt University and Theragen AG, Germany. "Therefore, gene modified tumor cells with vectors for the expression of B7 have been extensively studied in experimental tumor cell vaccination."
The researchers investigated the role of costimulation through B7.1 and its receptor, the CD28 molecule, in the generation of cytotoxic T cells (CTLs) against MCF-7 breast...
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Source: Gene Therapy Weekly (2000-02-10)
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