Allograft Survival
Engineered Dendritic Cells Induce Hyporesponsiveness
Published in Gene Therapy Weekly, February 10th, 2000
"Polarization of an immune response toward tolerance or immunity is dictated by the interactions between T cells and dendritic cells (DC), which in turn are modulated by the expression of distinct cell surface molecules, and the cytokine milieu in which these interactions are taking place," wrote W. P. Min and colleagues from the Toronto Hospital, Canada. "Genetic modification of DC with genes coding for specific immunoregulatory cell surface molecules and cytokines offers the potential of inhibiting immune responses by...
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Source: Gene Therapy Weekly (2000-02-10)
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