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Leishmania amazonensis

Episomal Expression of Specific Sense and Antisense mRNAs Evaluated

Published in Gene Therapy Weekly, February 17th, 2000

Researchers from the United States evaluated episomal expression of specific sense and antisense mRNAs of Leishmania amazonensis.

"The major surface glycoprotein (gp63) of Leishmania amazonensis is a metalloprotease implicated in the infection of mammalian macrophages," stated D. Q. Chen and colleagues from the Finch University Health Sciences Chicago Medical School, Illinois. "The expression of gp63 and its participation in this infection were further examined by modulating the level of this molecule in a virulent gp63-abundant wild-type clone."

Chen et al. published the results of their study in the journal Infection and...

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