Apoptosis

Regulation of bcl-2 Family Members Leads to rAD-p5-Mediated Apoptosis

Published in Gene Therapy Weekly, March 9th, 2000

rAD-p53-mediated apoptosis can be induced by regulation of bcl-2 family and caspases, according to recent study findings.

Isabella Atencio and G. William Demers examined the regulation of pro-apoptotic and anti-apoptotic gene products in response to exogenous p53 by adenovirus-mediated transfer of wild-type p53 gene (rAD-p53) in HLF, a hepatocellular carcinoma cell line. They reported their study, titled "Apoptosis in a hepatocellular carcinoma cell line in response to adenovirus-mediated transfer of wild-type p53 gene occurs by regulation of bcl-2 family members and activation of caspases," at Gene Therapy of Cancer VIII, held December 9-11, 1999, in San...

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Source: Gene Therapy Weekly (2000-03-09)

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