Liver Disease

Reversibly Immortalized Hepatocytes May Increase Transplant Possibilities

Published in Gene Therapy Weekly, April 6th, 2000

A new technique for preserving liver cells may increase the availability of hepatocytes used to sustain patients awaiting liver transplant.

"Because of a critical shortage in suitable organs, many patients with terminal liver disease die each year before liver transplantation can be performed," explained N. Kobayashi and colleagues at Okayama University in Japan ("Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes," Science, 2000;287(5456):1258-1262).

Some researchers have suggested transplanting isolated hepatocytes to stabilize these patients; however, according to Kobayashi et al., there is currently no...

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Source: Gene Therapy Weekly (2000-04-06)

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