Cerebral Vasospasm

Endothelial Nitric Oxide Synthase Gene Transfer Evaluated

Published in Gene Therapy Weekly, May 4th, 2000

Nitric oxide plays a regulatory role in cerebral artery relaxation to bradykinin, according to a presentation at the 25th International Stroke Conference, held in New Orleans, Louisiana. .

"Recombinant eNOS gene transfer is being investigated as a putative therapeutic option for cardiovascular diseases, including cerebral vasospasm," noted Vini G. Khurana and colleagues from Mayo Clinic, Minnesota, USA. "The aim of the present study was to determine the effects of recombinant eNOS gene transfer on vascular reactivity of normal human cerebral arteries."

The researchers conducted isometric force recording of isolated pial arteries (sized 500-1000...

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Source: Gene Therapy Weekly (2000-05-04)

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