Cancer Gene Therapy

p53-Mediated Growth Suppression Enhanced By Chemotherapy

Published in Gene Therapy Weekly, May 4th, 2000

Wild-type p53 gene-transfer-mediated growth suppression of human ovarian carcinoma can be enhanced by chemotherapy.

"The aim of this work was to observe the growth and chemosensitivity of human ovarian cancer OV-MZ-2a and OV-MZ-32 cells following adenovirus-based wild-type p53 (Ad-p53) gene transfer alone or combined with chemotherapeutic agents," wrote Q. Wu and colleagues, State University of New York, USA.

Wu et al. published their study in the Journal of Cancer Research and Clinical Oncology ("Growth suppression of human ovarian carcinoma OV-MZ-2a and OV-MZ-32 cells mediated by gene transfer of wild-type p53 enhanced by chemotherapy in...

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Source: Gene Therapy Weekly (2000-05-04)

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