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Myocardial Gene Therapy

Global Perfusion Versus Regional Administration Examined

Published in Gene Therapy Weekly, May 18th, 2000

Strategies for administration of vectors for myocardial gene therapy were examined by researchers from the United States.

"Global perfusion (GP) and intramyocardial (IM) vector administration represent alternative strategies for cardiac gene therapy," said Leonard Y. Lee and colleagues from the New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, in a second presentation to the 49th Annual Scientific Session of the American College of Cardiology, held in Anaheim, California. "While IM delivery has been shown to provide high local transgene concentrations, GP delivery may be an ideal method of gene transfer when global treatment is...

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