Published in Gene Therapy Weekly, June 8th, 2000
"Transfer of the HSV-tk gene followed by the administration of ganciclovir (GCV) into hepatocellular carcinoma (HCC)-derived cell lines either in vitro or transplanted into nude mice has been shown to provide a potential strategy for HSV-tk-based gene therapy of HCC," stated R. Gerolami and colleagues, Institute Gustave Roussy, France. "We report herein an analysis of the antitumoral efficacy of two recombinant adenoviruses (Ads), Ad.CMVtk and Ad.AFPtk, in a relevant model of multifocal hepatic lesions induced...
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