Antisense Therapy
Complete Reversal of Multidrug Resistance Phenotype Not Possible in Leukemia Cells
Published in Gene Therapy Weekly, June 15th, 2000
"The purpose of the current study was to characterize the effect of chimeric AS-ODNs encapsulated with cationic lipids on MDR in human leukemia cells and to determine if this modification of the ODN alone or in combination with the cationic lipid might offer advantages over classical ODN treatment with free unmodulated or phosphorothiolated AS-ODNs," wrote H. Dassow and colleagues, University of Leipzig, Germany. "Furthermore, we extended the antisense method to the use of...
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Source: Gene Therapy Weekly (2000-06-15)
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