Arthritis Gene Therapy
Adeno-Associated Viral Vectors Ideal for in vivo Gene Therapy
Published in Gene Therapy Weekly, June 15th, 2000
According to J. Goater and colleagues, University of Rochester, New York, "A recombinant AAV (rAAV) vector expressing the bacterial beta-galactosidase (beta-gal) gene (rAAV-CMV-LacZ) was directly introduced into healthy-normal mouse knees, or arthritic knees in mice overexpressing tumor necrosis factor-alpha (hTNF alpha-Tg)" ("Empirical advantages of adenoassociated viral vectors for in vivo gene therapy for arthritis," Journal of Rheumatology, 2000;27(4):983-989).
The researchers used immunohistochemistry and...
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Source: Gene Therapy Weekly (2000-06-15)
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