Published in Gene Therapy Weekly, June 15th, 2000
"SCID-X1 is an X-linked inherited disorder characterized by an early block in T and natural killer (NK) lymphocyte differentiation," wrote M. Cavazzana-Calvo and colleagues, Hopital Necker Enfants Maladaies, France. "This block is caused by mutations of the gene encoding the gamma c cytokine receptor subunit of interleukin-2, -4, -7, -9, and -15 receptors, which participates in the delivery of growth, survival, and differentiation signals to early lymphoid progenitors."
After successful preclinical studies,...
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