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Vector Development

Transgene Expression in Human Corneal Cells Mediated by Lentivirus Vector

Published in Gene Therapy Weekly, June 29th, 2000

Efficient, sustained expression of a transgene in human corneal cells was mediated by a lentiviral vector, researchers in the United States report.

"The development of vectors and techniques able to transfer potentially therapeutic genetic information to corneal tissues efficiently may have broad clinical applications," stated X. Wang and colleagues, University of Southern California. "Although a variety of vectors have been tested for their ability to transduce corneal tissue, these systems have been ineffective at transducing all cell types or have been associated with a relatively short duration of transgene expression. Towards the implementation of efficient,...

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