Published in Gene Therapy Weekly, July 6th, 2000
"Many gene therapy strategies would be enhanced by efficient transfer of multiple genes into the same cell," said H.M. Karpoff and colleagues, Memorial Sloan Kettering Cancer Center, New York. "Herpes simplex viral amplicon (HSV) vectors are good vehicles for gene transfer because they accommodate large pieces of foreign DNA and transfer genes rapidly and efficiently. The current studies examine whether efficient cotransduction of tumor cells can be accomplished using multiple HSV vectors in a manner useful for clinical...
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