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HIV Gene Therapy

RNA-Based Strategy Inhibits HIV

Published in Gene Therapy Weekly, July 6th, 2000

Researchers in the United States have developed a RNA-based gene therapy strategy for the control of HIV.

"We have developed multiple inhibitory RNA-based strategies targeted to various steps of the HIV life cycle," reported Laurence Gagnon and colleagues from the Beckman Research Institute of City of Hope, California. "We have already demonstrated strong HIV inhibition by ribozymes, Rev or Tat binding aptamers, tRNAlys3-ribozyme chimeric RNAs, and anti-CCR5 ribozymes."

Cagnon et al. presented data from their study at the Keystone Symposium, "Novel Biological Approaches to HIV-1 Infection Based on New Insights into HIV Biology," held in...

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